Motif ID: TLX1..3_NFIC{dimer}.p2

Z-value: 1.070


Transcription factors associated with TLX1..3_NFIC{dimer}.p2:

Gene SymbolEntrez IDGene Name
TLX1 3195 T-cell leukemia homeobox 1
TLX3 30012 T-cell leukemia homeobox 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TLX1hg19_v1_chr10_+_102891060_1028912970.098.7e-01Click!


Activity profile for motif TLX1..3_NFIC{dimer}.p2.

activity profile for motif TLX1..3_NFIC{dimer}.p2


Sorted Z-values histogram for motif TLX1..3_NFIC{dimer}.p2

Sorted Z-values for motif TLX1..3_NFIC{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX1..3_NFIC{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_129519420 2.092 NM_178471
GPR119
G protein-coupled receptor 119
chr3_-_12200339 1.550 TIMP4
TIMP metallopeptidase inhibitor 4
chr1_+_203595897 1.548 NM_001001396
NM_001684
ATP2B4

ATPase, Ca++ transporting, plasma membrane 4

chr5_-_111093251 1.306 NM_001142479
NM_001142480
NM_001142478
C5orf13


chromosome 5 open reading frame 13


chr19_+_10397642 1.300 NM_001039132
NM_001544
NM_022377
ICAM4


intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)


chr1_+_203595929 1.284 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr19_-_35454952 1.227 NM_175872
ZNF792
zinc finger protein 792
chr19_-_35454867 1.167 ZNF792
zinc finger protein 792
chrX_+_106171328 1.166 CLDN2
claudin 2
chr5_-_111092918 1.127 NM_004772
C5orf13
chromosome 5 open reading frame 13
chr7_-_16844606 1.122 NM_006408
AGR2
anterior gradient 2 homolog (Xenopus laevis)
chr5_-_111092865 1.116 C5orf13
chromosome 5 open reading frame 13
chr5_-_111093030 1.111 NM_001142482
NM_001142481
C5orf13

chromosome 5 open reading frame 13

chr3_-_12200850 1.093 NM_003256
TIMP4
TIMP metallopeptidase inhibitor 4
chr1_-_160001529 1.061 PIGM
phosphatidylinositol glycan anchor biosynthesis, class M
chr19_+_15751706 0.978 NM_000896
NM_001199208
NM_001199209
CYP4F3


cytochrome P450, family 4, subfamily F, polypeptide 3


chr17_-_76921076 0.952 TIMP2
TIMP metallopeptidase inhibitor 2
chr1_-_16539103 0.930 NM_153213
ARHGEF19
Rho guanine nucleotide exchange factor (GEF) 19
chr1_+_200993041 0.926


chr1_+_203596222 0.903 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr7_+_1127722 0.854 NM_001098201
GPER
G protein-coupled estrogen receptor 1
chr17_-_76921205 0.848 TIMP2
TIMP metallopeptidase inhibitor 2
chr17_-_76975932 0.835 NM_005567
LGALS3BP
lectin, galactoside-binding, soluble, 3 binding protein
chr6_+_135502521 0.803 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr14_+_95047792 0.770 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr3_-_14989616 0.735 LOC100505641
uncharacterized LOC100505641
chr2_+_66662692 0.715 MEIS1
Meis homeobox 1
chr22_-_33402648 0.710 NM_003490
NM_133633
SYN3

synapsin III

chr1_-_220101781 0.704


chr14_+_85996512 0.691 FLRT2
fibronectin leucine rich transmembrane protein 2
chr11_-_2159472 0.684 IGF2
insulin-like growth factor 2 (somatomedin A)
chr15_+_66994669 0.670 NM_005585
SMAD6
SMAD family member 6
chr20_+_33759773 0.660 NM_006404
PROCR
protein C receptor, endothelial
chr16_-_28550324 0.638 NM_001042483
NM_012385
NUPR1

nuclear protein, transcriptional regulator, 1

chr12_-_56106061 0.634 NM_001144997
ITGA7
integrin, alpha 7
chr17_-_76921453 0.634 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr10_+_82173574 0.631 NM_001243778
NM_001243782
C10orf58

chromosome 10 open reading frame 58

chr3_-_14989399 0.623 LOC100505641
uncharacterized LOC100505641
chr1_-_220101925 0.621 NM_018713
SLC30A10
solute carrier family 30, member 10
chr2_+_66662516 0.620 NM_002398
MEIS1
Meis homeobox 1
chr1_-_23886284 0.612 NM_002167
ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr6_+_24495166 0.611 NM_001080
NM_170740
ALDH5A1

aldehyde dehydrogenase 5 family, member A1

chr20_+_34742656 0.608 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr3_-_197300193 0.598 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr1_+_145477018 0.590 NM_153713
LIX1L
Lix1 homolog (mouse)-like
chr14_+_95047730 0.581 NM_000624
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr9_+_74764266 0.579 NM_001242505
NM_001242506
NM_004293
GDA


guanine deaminase


chr17_+_7184978 0.575 NM_001042
SLC2A4
solute carrier family 2 (facilitated glucose transporter), member 4
chr8_-_30002199 0.567 NM_001100916
MBOAT4
membrane bound O-acyltransferase domain containing 4
chrX_+_106161589 0.567 NM_001171095
CLDN2
claudin 2
chr18_-_74728677 0.560 MBP
myelin basic protein
chr12_+_66218141 0.556 NM_003483
NM_003484
HMGA2

high mobility group AT-hook 2

chr15_+_45248902 0.547 NM_152448
C15orf43
chromosome 15 open reading frame 43
chr14_+_85996454 0.546 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr21_+_40823779 0.544 NM_007341
SH3BGR
SH3 domain binding glutamic acid-rich protein
chr7_+_94285736 0.544 PEG10
paternally expressed 10
chr7_+_94285620 0.540 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr6_-_30128688 0.534 NM_006778
NM_052828
TRIM10

tripartite motif containing 10

chr14_+_95047758 0.532 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr15_-_90347534 0.524 ANPEP
alanyl (membrane) aminopeptidase
chr9_+_74764382 0.522 GDA
guanine deaminase
chr3_-_195938256 0.520 NM_001039617
ZDHHC19
zinc finger, DHHC-type containing 19
chr1_-_173174611 0.515 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr3_-_14989857 0.512 LOC100505641
uncharacterized LOC100505641
chr17_+_7211693 0.512 NM_001143762
EIF5A
eukaryotic translation initiation factor 5A
chr1_+_173837492 0.510 NM_001122770
NM_032522
ZBTB37

zinc finger and BTB domain containing 37

chr12_+_7169192 0.505


chr8_-_18541441 0.504 PSD3
pleckstrin and Sec7 domain containing 3
chr12_-_25055966 0.502 NM_001178093
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr6_-_38670920 0.500 GLO1
glyoxalase I
chr4_-_103245468 0.499 NM_001135148
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr15_-_40630272 0.497 C15orf52
chromosome 15 open reading frame 52
chr2_+_27070962 0.492 NM_020134
NM_001253723
NM_001253724
DPYSL5


dihydropyrimidinase-like 5


chr8_-_17104266 0.480 NM_013354
NM_054026
CNOT7

CCR4-NOT transcription complex, subunit 7

chr10_-_21785873 0.479 C10orf114
chromosome 10 open reading frame 114
chr20_+_58515408 0.478 NM_001190827
NM_022106
C20orf177

chromosome 20 open reading frame 177

chrX_+_99899162 0.477 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr10_+_45455149 0.477 NM_032023
RASSF4
Ras association (RalGDS/AF-6) domain family member 4
chr2_-_233877901 0.473 NGEF
neuronal guanine nucleotide exchange factor
chr6_+_24495016 0.473 ALDH5A1
aldehyde dehydrogenase 5 family, member A1
chr16_-_51185150 0.472 NM_002968
SALL1
sal-like 1 (Drosophila)
chr12_+_100867550 0.470 NM_001206977
NM_001206978
NM_001206979
NM_005123
NR1H4



nuclear receptor subfamily 1, group H, member 4



chr17_-_27948345 0.468 NM_032854
CORO6
coronin 6
chr5_-_73937248 0.467 NM_003633
ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chr17_+_38599651 0.466 NM_001552
IGFBP4
insulin-like growth factor binding protein 4
chr15_+_90895476 0.450 NM_001004309
ZNF774
zinc finger protein 774
chrX_-_13956644 0.447 NM_001001994
GPM6B
glycoprotein M6B
chr4_-_155412867 0.447 NM_001142552
NM_001142553
DCHS2

dachsous 2 (Drosophila)

chr22_+_33196801 0.440 NM_000362
TIMP3
TIMP metallopeptidase inhibitor 3
chr11_-_66313509 0.438 NM_207340
ZDHHC24
zinc finger, DHHC-type containing 24
chr15_-_90347173 0.438 ANPEP
alanyl (membrane) aminopeptidase
chr14_-_105261850 0.438 AKT1
v-akt murine thymoma viral oncogene homolog 1
chr16_+_57662301 0.436 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr15_-_40633122 0.433 NM_207380
C15orf52
chromosome 15 open reading frame 52
chr12_+_67663364 0.426 CAND1
cullin-associated and neddylation-dissociated 1
chr18_-_24129084 0.424 NM_001136205
KCTD1
potassium channel tetramerisation domain containing 1
chr1_+_220960038 0.419 NM_022746
MARC1
mitochondrial amidoxime reducing component 1
chrX_+_134124967 0.415 NM_001163438
CXorf69
chromosome X open reading frame 69
chr11_-_57089670 0.411 TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr17_+_7210929 0.408 EIF5A
eukaryotic translation initiation factor 5A
chr1_+_179262848 0.408 NM_001252511
NM_001252512
NM_003101
SOAT1


sterol O-acyltransferase 1


chr7_+_94285676 0.406 NM_001172437
NM_001172438
PEG10

paternally expressed 10

chr12_+_100867739 0.405 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr1_+_84767288 0.404 NM_001134663
SAMD13
sterile alpha motif domain containing 13
chr10_-_100174891 0.399 NM_032709
PYROXD2
pyridine nucleotide-disulphide oxidoreductase domain 2
chr3_+_100328432 0.397 NM_032787
GPR128
G protein-coupled receptor 128
chr12_+_74931550 0.397 NM_001136262
ATXN7L3B
ataxin 7-like 3B
chr10_+_88718287 0.394 NM_003087
SNCG
synuclein, gamma (breast cancer-specific protein 1)
chr16_+_57406398 0.388 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr11_-_114271052 0.384 NM_019021
C11orf71
chromosome 11 open reading frame 71
chrX_-_125300079 0.382 NM_001013628
DCAF12L2
DDB1 and CUL4 associated factor 12-like 2
chr6_-_38670871 0.382 GLO1
glyoxalase I
chr1_+_179262960 0.381 SOAT1
sterol O-acyltransferase 1
chr8_-_17104103 0.379 CNOT7
CCR4-NOT transcription complex, subunit 7
chrX_+_149613719 0.377 NM_001177466
NM_005491
MAMLD1

mastermind-like domain containing 1

chr1_-_161193375 0.377 NM_001643
APOA2
apolipoprotein A-II
chr12_+_16506350 0.372 NM_145764
MGST1
microsomal glutathione S-transferase 1
chr9_+_35673852 0.372 NM_001216
CA9
carbonic anhydrase IX
chr11_-_66313474 0.371 ZDHHC24
zinc finger, DHHC-type containing 24
chr9_+_74764417 0.370 GDA
guanine deaminase
chr6_+_39760772 0.369 NM_015345
DAAM2
dishevelled associated activator of morphogenesis 2
chr3_-_107809754 0.369 NM_001777
NM_198793
CD47

CD47 molecule

chr6_-_38670882 0.369 GLO1
glyoxalase I
chr6_-_38670829 0.367 GLO1
glyoxalase I
chr7_+_73624328 0.365 LAT2
linker for activation of T cells family, member 2
chr1_+_215178884 0.362 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr2_-_47142939 0.362 MCFD2
multiple coagulation factor deficiency 2
chr8_-_42065193 0.359 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr20_-_44519629 0.359 NM_080749
NEURL2
neuralized homolog 2 (Drosophila)
chr3_-_50360109 0.356 NM_003773
NM_033158
HYAL2

hyaluronoglucosaminidase 2

chr19_+_10543110 0.354 NM_001111309
PDE4A
phosphodiesterase 4A, cAMP-specific
chr4_-_104020964 0.352 NM_020139
BDH2
3-hydroxybutyrate dehydrogenase, type 2
chr6_-_38670904 0.352 GLO1
glyoxalase I
chr1_+_179262888 0.351 SOAT1
sterol O-acyltransferase 1
chr2_+_85766291 0.347 MAT2A
methionine adenosyltransferase II, alpha
chr6_-_38670915 0.346 GLO1
glyoxalase I
chr19_-_23456964 0.345 LOC100132815
importin 5 pseudogene
chr1_+_179262936 0.337 SOAT1
sterol O-acyltransferase 1
chr1_+_154377847 0.335 IL6R
interleukin 6 receptor
chr2_-_25474948 0.335 NM_153759
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chrX_+_2746810 0.331 NM_001079855
NM_001184702
NM_001184703
NM_001184704
NM_003918
GYG2




glycogenin 2




chr14_+_96829849 0.330 C14orf129
chromosome 14 open reading frame 129
chr21_+_33031932 0.330 NM_000454
SOD1
superoxide dismutase 1, soluble
chr9_+_116356199 0.330 NM_144489
RGS3
regulator of G-protein signaling 3
chr1_+_116184573 0.329 NM_001172411
NM_138959
VANGL1

vang-like 1 (van gogh, Drosophila)

chr4_+_123653856 0.329 NM_001178007
NM_152618
BBS12

Bardet-Biedl syndrome 12

chr14_+_96858436 0.328 NM_152327
AK7
adenylate kinase 7
chr1_-_231114596 0.327 TTC13
tetratricopeptide repeat domain 13
chr2_-_233877920 0.326 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr11_+_116700620 0.323 NM_000040
APOC3
apolipoprotein C-III
chrX_+_105855159 0.323 NM_001184782
NM_018015
CXorf57

chromosome X open reading frame 57

chr7_-_150652861 0.320 NM_001204798
NM_172057
KCNH2

potassium voltage-gated channel, subfamily H (eag-related), member 2

chr17_+_57642885 0.316 NM_001166301
NM_024612
DHX40

DEAH (Asp-Glu-Ala-His) box polypeptide 40

chr2_+_158114109 0.310 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr3_-_52488030 0.310 NM_003280
TNNC1
troponin C type 1 (slow)
chr14_+_36295515 0.308 NM_032352
BRMS1L
breast cancer metastasis-suppressor 1-like
chr22_+_21986968 0.308 NM_152612
CCDC116
coiled-coil domain containing 116
chr2_+_177016112 0.306 NM_014621
HOXD4
homeobox D4
chr3_+_190231839 0.306 NM_001167928
NM_001167929
NM_001167930
NM_001167931
NM_002182
NM_134470
IL1RAP





interleukin 1 receptor accessory protein





chr6_+_14117857 0.305 NM_001040280
NM_004233
CD83

CD83 molecule

chr1_-_16344438 0.304 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr2_-_47143250 0.299 NM_001171507
NM_001171510
MCFD2

multiple coagulation factor deficiency 2

chr6_+_132129154 0.299 NM_006208
ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr9_+_74764394 0.297 GDA
guanine deaminase
chr1_-_153585504 0.297 NM_080388
S100A16
S100 calcium binding protein A16
chr6_-_2635297 0.296 NM_152554
C6orf195
chromosome 6 open reading frame 195
chr1_+_154378044 0.293 IL6R
interleukin 6 receptor
chr7_-_5569200 0.291 ACTB
actin, beta
chr20_+_44519590 0.290 NM_000308
NM_001127695
NM_001167594
CTSA


cathepsin A


chr1_-_231114606 0.290 TTC13
tetratricopeptide repeat domain 13
chr17_-_15164043 0.289 NM_153322
PMP22
peripheral myelin protein 22
chr10_+_104503711 0.288 C10orf26
chromosome 10 open reading frame 26
chr2_+_150187028 0.287 NM_194317
LYPD6
LY6/PLAUR domain containing 6
chr12_-_72057389 0.287


chr15_-_72523448 0.286 PKM2
pyruvate kinase, muscle
chr1_-_151345156 0.285 NM_003944
SELENBP1
selenium binding protein 1
chrX_+_46937889 0.285 RGN
regucalcin (senescence marker protein-30)
chr16_-_3285359 0.284 NM_001145448
NM_198088
NM_001145446
NM_198087
ZNF200



zinc finger protein 200



chr3_-_11610264 0.280 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr6_+_132129195 0.280 ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr3_+_53880606 0.277 IL17RB
interleukin 17 receptor B
chr16_-_28550227 0.276 NUPR1
nuclear protein, transcriptional regulator, 1
chr10_+_106034886 0.275 NM_001191014
NM_001191015
GSTO2

glutathione S-transferase omega 2

chr7_-_150000068 0.273 NM_001164459
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr1_+_231114839 0.272


chr9_+_74764354 0.271 GDA
guanine deaminase
chr1_-_231114580 0.270 TTC13
tetratricopeptide repeat domain 13
chr3_-_50340979 0.270 NM_007312
NM_033159
NM_153282
NM_153283
NM_153285
HYAL1




hyaluronoglucosaminidase 1




chr17_+_7211260 0.270 NM_001143761
EIF5A
eukaryotic translation initiation factor 5A
chr3_+_170139027 0.269 NM_001185056
CLDN11
claudin 11
chr1_-_1850704 0.269 NM_178545
TMEM52
transmembrane protein 52
chr17_+_7210841 0.268 NM_001970
EIF5A
eukaryotic translation initiation factor 5A
chr1_-_231114617 0.266 NM_001122835
NM_024525
TTC13

tetratricopeptide repeat domain 13

chr1_-_161193190 0.265 APOA2
apolipoprotein A-II
chr15_-_90358057 0.265 NM_001150
ANPEP
alanyl (membrane) aminopeptidase
chr10_+_135160843 0.264 NM_001145201
NM_145202
PRAP1

proline-rich acidic protein 1

chr8_-_62602285 0.264 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr1_-_23857284 0.261 E2F2
E2F transcription factor 2
chr3_-_185655648 0.260 TRA2B
transformer 2 beta homolog (Drosophila)
chr15_-_72523483 0.259 PKM2
pyruvate kinase, muscle

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.